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Reaction Details
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TargetCarbonic anhydrase 2
LigandBDBM10886
Substrate/Competitorn/a
Meas. Tech.CA Inhibition Assay
pH8.3±0
Temperature298.15±0 K
Ki 4.6e+2±n/a nM
Citation Maresca, AScozzafava, AVullo, DSupuran, CT Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three ß-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem28:384-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrase 2
Synonyms:β-Carbonic anhydrase 2 (CA 2) | Carbonic anhydrase | MTCA2_MYCTU | canB | cynT | mtcA2
Type:Enzyme
Mol. Mass.:21788.97
Organism:Mycobacterium tuberculosis
Description:P9WPJ9
Residue:207
Sequence:
MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEI
IFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDG
TLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSL
AIVGVTYQLDDGRAVLRDHIGNIGEEV
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BDBM10886
n/a
NameBDBM10886
Synonyms:2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | BZA1 | Benzolamide | Benzolamide (BZA) | CHEMBL73962
TypeSmall organic molecule
Emp. Form.C8H8N4O4S3
Mol. Mass.320.369
SMILESNS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1
Structure
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