| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
|---|
| Ligand | BDBM239155 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 277.15±n/a K |
|---|
| Ki | >2.00e+5±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Bonneau, A; Maresca, A; Winum, JY; Supuran, CT Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem28:397-401 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 2 |
|---|
| Name: | Carbonic anhydrase 2 |
|---|
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29250.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00918 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
|---|
| BDBM239155 |
|---|
| n/a |
|---|
| Name | BDBM239155 |
|---|
| Synonyms: | 7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-methylcoumarine (1a) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15N3O5 |
|---|
| Mol. Mass. | 329.3074 |
|---|
| SMILES | Cc1ncc(n1CCOc1ccc2c(C)cc(=O)oc2c1)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
