| Reaction Details |
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 | Report a problem with these data |
| Target | Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085] |
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| Ligand | BDBM162183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Bub1 Kinase Assay |
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| pH | 8±n/a |
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| IC50 | 15000±n/a nM |
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| Comments | extracted |
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| Citation |  Bärfacker, L; Prechtl, S; Siemeister, G; Wengner, AM; Ackerstaff, J; Nowak-Reppel, K; Bader, B; Lienau, P; Stöckigt, D; Heinrich, T Amino-substituted isothiazoles US Patent US9682995 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085] |
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| Name: | Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085] |
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| Synonyms: | BUB1 | BUB1L | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085) |
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| Type: | n/a |
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| Mol. Mass.: | 43624.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43683[704-1085] |
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| Residue: | 382 |
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| Sequence: | DAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPN
TFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQ
KPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKN
TPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLA
LIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTY
MKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYT
NKIRALRNRLIVLLLECKRSRK
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| BDBM162183 |
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| n/a |
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| Name | BDBM162183 |
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| Synonyms: | US9682995, 82 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10F5N5OS |
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| Mol. Mass. | 415.341 |
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| SMILES | Cc1nsc(Nc2cncc(n2)C(F)(F)F)c1C(=O)Nc1ccc(F)c(F)c1 |
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| Structure | 
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