| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM240262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Kinetics Assay |
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| pH | 7.6±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 2600±n/a nM |
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| Comments | extracted |
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| Citation |  Thatcher, GR; Schiefer, IT; Arancio, O; Mauro, F Cysteine protease inhibitors and uses thereof US Patent US9403843 Publication Date 8/2/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_PIG | CANP 1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain 1 | Calpain mu-type | Calpain-1 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Micromolar-calpain | muCANP |
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| Type: | Catalytic subunit; forms a heterodimer with a small (regulatory) subunit (CAPNS1) |
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| Mol. Mass.: | 81729.82 |
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| Organism: | Sus scrofa (pig) |
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| Description: | Native calpain-1 from porcine erythrocytes, purchased from Calbiochem, was used in assay. |
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| Residue: | 714 |
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| Sequence: | MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEA
FPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILK
ALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKS
QRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSF
VLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSE
EEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM240262 |
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| n/a |
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| Name | BDBM240262 |
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| Synonyms: | US9403843, 33 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15FN4O5S2 |
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| Mol. Mass. | 462.475 |
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| SMILES | OC(=O)[C@@H]1O[C@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)Nc1nc(cs1)-c1ccc(F)cc1 |r| |
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| Structure | 
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