| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Ligand | BDBM240714 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| Kd | 20±n/a nM |
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| Citation |  Papeo, GM; Cirla, A; D'Anello, M; Scolaro, A; Zuccotto, F 3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors US Patent US9422243 Publication Date 8/23/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Synonyms: | (ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60071.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6F1[R100H] |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM240714 |
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| n/a |
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| Name | BDBM240714 |
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| Synonyms: | US9422243, 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13BrF2N2O2 |
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| Mol. Mass. | 395.198 |
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| SMILES | NCCOc1c([nH]c(=O)c2c(F)c(F)ccc12)-c1ccc(Br)cc1 |
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| Structure | 
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