| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic elongation factor 2 kinase |
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| Ligand | BDBM293960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase-Glo luminescent kinase assay |
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| IC50 | 400±n/a nM |
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| Citation |  Dodd, JH Compounds inhibiting eukaryotic elongation factor 2 kinase activity US Patent US10106552 Publication Date 10/23/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic elongation factor 2 kinase |
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| Name: | Eukaryotic elongation factor 2 kinase |
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| Synonyms: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K |
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| Type: | Protein |
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| Mol. Mass.: | 82116.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 725 |
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| Sequence: | MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYY
SNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAV
TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDV
YFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYN
SNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNL
GVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSP
QVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDN
MASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGR
VCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFC
EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY
LLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQ
DEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAW
AQMEE
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| BDBM293960 |
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| n/a |
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| Name | BDBM293960 |
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| Synonyms: | US10106552, Compound 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N4OS2 |
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| Mol. Mass. | 358.481 |
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| SMILES | CC1(C)CCc2c(C1)nc1sc(C(N)=O)c(N)c1c2-c1cncs1 |
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| Structure | 
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