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TargetCoagulation factor IX
LigandBDBM241405
Substrate/CompetitorUS9409908, pyroGlu-Pro-Arg-pNA
Meas. Tech.In Vitro Assay
pH7.4±n/a
Ki 0.87±n/a nM
Commentsextracted
Citation Yang, W; Corte, JR; Gilligan, PJ; Pinto, DJ; Ewing, WR; Dilger, AK; Wang, Y; Fang, T; Pabbisetty, KB; Smith, II, LM Dihydropyridone p1 as factor XIa inhibitors US Patent US9409908 Publication Date 8/9/2016
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:P00740
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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  Blast E-value cutoff:
BDBM241405
US9409908, pyroGlu-Pro-Arg-pNA
NameBDBM241405
Synonyms:US9409908, 37 | US9951071, Example 37
TypeSmall organic molecule
Emp. Form.C32H29ClF2N6O3
Mol. Mass.619.061
SMILESC[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)ccc(Cl)c2F)c2ccnc(c2)-c2ccc(Nc3nnc(C)o3)cc2NC1=O |r,c:9|
Structure
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