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TargetCoagulation factor IX
LigandBDBM241451
Substrate/CompetitorUS9409908, pyroGlu-Pro-Arg-pNA
Meas. Tech.In Vitro Assay
pH7.4±n/a
Ki 0.06±n/a nM
Commentsextracted
Citation Yang WCorte JRGilligan PJPinto DJEwing WRDilger AKWang YFang TPabbisetty KBSmith, II LM Dihydropyridone p1 as factor XIa inhibitors US Patent  US9409908 Publication Date 8/9/2016
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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  Blast E-value cutoff:
BDBM241451
US9409908, pyroGlu-Pro-Arg-pNA
NameBDBM241451
Synonyms:US9409908, 83
TypeSmall organic molecule
Emp. Form.C33H29ClF2N4O4
Mol. Mass.619.058
SMILESC[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)ccc(Cl)c2F)c2cc(ccn2)-c2cc3c(C(O)=O)c(C)[nH]c3cc2NC1=O |r,c:9|
Structure
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