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TargetCoagulation factor IX
LigandBDBM241468
Substrate/CompetitorUS9409908, pyroGlu-Pro-Arg-pNA
Meas. Tech.In Vitro Assay
pH7.4±n/a
Ki 0.09±n/a nM
Commentsextracted
Citation Yang, WCorte, JRGilligan, PJPinto, DJEwing, WRDilger, AKWang, YFang, TPabbisetty, KBSmith, II, LM Dihydropyridone p1 as factor XIa inhibitors US Patent US9409908 Publication Date 8/9/2016
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:P00740
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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  Blast E-value cutoff:
BDBM241468
US9409908, pyroGlu-Pro-Arg-pNA
NameBDBM241468
Synonyms:US9409908, 100 | US9951071, Example 100
TypeSmall organic molecule
Emp. Form.C32H31ClFN7O2
Mol. Mass.600.086
SMILESCC(C)[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)c(Cl)ccc2-n2cnnn2)c2cc(ccn2)-c2ccccc2NC1=O |r,c:11|
Structure
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