Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine-protein kinase Lyn
LigandBDBM243041
Substrate/Competitorn/a
Meas. Tech.In Vitor Src Tyrosine Kinase Activity Assay
Temperature295.15±0 K
IC50 0.3±0.0 nM
Citation Dincer SCetin KTOnay-Besikci AÍlgen S Synthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors. J Enzyme Inhib Med Chem 28:1080-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Lyn
Name:Tyrosine-protein kinase Lyn
Synonyms:JTK8 | LYN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:Protein
Mol. Mass.:58575.92
Organism:Homo sapiens (Human)
Description:P07948
Residue:512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM243041
n/a
NameBDBM243041
Synonyms:A-419259
TypeSmall organic molecule
Emp. Form.C29H34N6O
Mol. Mass.482.6199
SMILESCN1CCN(CC1)[C@H]1CCC(CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12 |r,wD:7.7,(26.44,-17.33,;25.67,-18.66,;25.16,-19.93,;25.3,-21.48,;23.96,-22.25,;24.33,-20.97,;24.33,-19.43,;22.48,-22.65,;22.48,-21.11,;21.14,-20.34,;19.81,-21.11,;19.81,-22.65,;21.14,-23.42,;18.32,-20.71,;19.23,-19.47,;18.32,-18.22,;18.8,-16.76,;20.3,-16.44,;20.78,-14.97,;19.75,-13.83,;20.22,-12.36,;21.73,-12.04,;22.76,-13.19,;24.27,-12.87,;24.74,-11.4,;23.71,-10.26,;22.21,-10.58,;18.24,-14.15,;17.77,-15.61,;16.86,-18.7,;15.52,-17.93,;15.52,-16.39,;14.19,-18.7,;14.19,-20.24,;15.52,-21.01,;16.86,-20.24,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: