| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [2420-3010,P2914L] |
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| Ligand | BDBM243456 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Surface Plasmon Resonance (SPR)-Based Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Kd | 3800±n/a nM |
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| KOFF | 2.20E-02 s-1 |
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| KON | 5.90E+03 M-1s-1 |
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| Comments | extracted |
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| Citation |  Vendeville, SM; Raboisson, PJ; Lin, T; Tahri, A; Amssoms, KI Macrocyclic indole derivatives useful as hepatitis C virus inhibitors US Patent US9427440 Publication Date 8/30/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [2420-3010,P2914L] |
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| Name: | Genome polyprotein [2420-3010,P2914L] |
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| Synonyms: | POLG_HCVJ4 | RNA-directed RNA polymerase (NS5B)(P495L) |
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| Type: | Enzyme |
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| Mol. Mass.: | 65782.25 |
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| Organism: | Hepatitis C virus genotype 1b (strain HC-J4) (HCV) |
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| Description: | P495L |
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| Residue: | 591 |
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| Sequence: | SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKSEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIY
QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPINSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPG
EINRVASCLRKLGVLPLRTWRHRARSVRAKLLSQGGRAATCGRYLFNWAVRTKLKLTPIP
AASQLDLSGWFVAGYSGGDIYHSLSRARPRWFPLCLLLLSVGVGIYLLPNR
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| BDBM243456 |
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| n/a |
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| Name | BDBM243456 |
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| Synonyms: | US9427440, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38N4O6S |
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| Mol. Mass. | 606.732 |
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| SMILES | COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25| |
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| Structure | 
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