Reaction Details |
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Target | Genome polyprotein [2420-3010,M2833T] |
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Ligand | BDBM243456 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Surface Plasmon Resonance (SPR)-Based Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Kd | 5.9±n/a nM |
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KOFF | 1.50E-04 s-1 |
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KON | 2.60E+04 M-1s-1 |
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Comments | extracted |
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Citation | Vendeville, SM; Raboisson, PJ; Lin, T; Tahri, A; Amssoms, KI Macrocyclic indole derivatives useful as hepatitis C virus inhibitors US Patent US9427440 Publication Date 8/30/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Genome polyprotein [2420-3010,M2833T] |
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Name: | Genome polyprotein [2420-3010,M2833T] |
Synonyms: | POLG_HCVJ4 | RNA-directed RNA polymerase (NS5B)(M414T) |
Type: | Enzyme |
Mol. Mass.: | 65736.12 |
Organism: | Hepatitis C virus genotype 1b (strain HC-J4) (HCV) |
Description: | M414T |
Residue: | 591 |
Sequence: | SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKSEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIY
QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPINSWLGNIITYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPG
EINRVASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRYLFNWAVRTKLKLTPIP
AASQLDLSGWFVAGYSGGDIYHSLSRARPRWFPLCLLLLSVGVGIYLLPNR
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BDBM243456 |
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n/a |
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Name | BDBM243456 |
Synonyms: | US9427440, 1 |
Type | Small organic molecule |
Emp. Form. | C32H38N4O6S |
Mol. Mass. | 606.732 |
SMILES | COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25| |
Structure |
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