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TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416]
LigandBDBM244794
Substrate/Competitorn/a
Meas. Tech.In Vitro Biological Assay
IC50 0.59±n/a nM
Citation Klaus, CRaimondi, MADaigle, SRPollock, RM Combination therapy for treating cancer US Patent US9446064 Publication Date 9/20/2016
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416]
Name:Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416]
Synonyms:DOT1L | DOT1L_HUMAN | Histone H3-K79 methyltransferase (DOT1L) | KIAA1814 | KMT4
Type:Protein
Mol. Mass.:47443.16
Organism:Homo sapiens (Human)
Description:Q8TEK3 aa 1-416
Residue:416
Sequence:
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP
EGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKK
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  Blast E-value cutoff:
BDBM244794
n/a
NameBDBM244794
Synonyms:US9446064, A75
TypeSmall organic molecule
Emp. Form.C31H43N7O3
Mol. Mass.561.7182
SMILESCC(C)N(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)[C@H]1C[C@H](CCc2nc3cc(ccc3[nH]2)C(C)(C)C)C1 |r,wU:7.12,5.4,22.24,wD:24.27,8.8,10.11,(4.17,6.58,;2.69,6.98,;2.29,8.46,;1.35,6.21,;.02,6.98,;-1.31,6.21,;-1.31,4.67,;-2.78,4.19,;-3.68,5.44,;-5.22,5.44,;-2.78,6.68,;-3.55,8.02,;-3.55,2.86,;-2.64,1.61,;-3.55,.36,;-5.01,.84,;-6.35,.07,;-6.35,-1.47,;-7.68,.84,;-7.68,2.38,;-6.35,3.15,;-5.01,2.38,;1.75,4.72,;3.09,3.95,;2.32,2.61,;2.71,1.13,;4.2,.73,;4.6,-.76,;5.85,-1.66,;5.37,-3.13,;6.14,-4.46,;5.37,-5.8,;3.83,-5.8,;3.06,-4.46,;3.83,-3.13,;3.35,-1.66,;6.14,-7.13,;5.37,-8.46,;7.68,-7.13,;6.91,-8.46,;.98,3.38,)|
Structure
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