Reaction Details | |||
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Target | Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | ||
Ligand | BDBM244794 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Biological Assay | ||
IC50 | 0.59±n/a nM | ||
Citation | Klaus, C; Raimondi, MA; Daigle, SR; Pollock, RM Combination therapy for treating cancer US Patent US9446064 Publication Date 9/20/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | |||
Name: | Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | ||
Synonyms: | DOT1L | DOT1L_HUMAN | Histone H3-K79 methyltransferase (DOT1L) | KIAA1814 | KMT4 | ||
Type: | Protein | ||
Mol. Mass.: | 47443.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q8TEK3 aa 1-416 | ||
Residue: | 416 | ||
Sequence: |
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BDBM244794 | |||
n/a | |||
Name | BDBM244794 | ||
Synonyms: | US9446064, A75 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H43N7O3 | ||
Mol. Mass. | 561.7182 | ||
SMILES | CC(C)N(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)[C@H]1C[C@H](CCc2nc3cc(ccc3[nH]2)C(C)(C)C)C1 |r,wU:7.12,5.4,22.24,wD:24.27,8.8,10.11,(4.17,6.58,;2.69,6.98,;2.29,8.46,;1.35,6.21,;.02,6.98,;-1.31,6.21,;-1.31,4.67,;-2.78,4.19,;-3.68,5.44,;-5.22,5.44,;-2.78,6.68,;-3.55,8.02,;-3.55,2.86,;-2.64,1.61,;-3.55,.36,;-5.01,.84,;-6.35,.07,;-6.35,-1.47,;-7.68,.84,;-7.68,2.38,;-6.35,3.15,;-5.01,2.38,;1.75,4.72,;3.09,3.95,;2.32,2.61,;2.71,1.13,;4.2,.73,;4.6,-.76,;5.85,-1.66,;5.37,-3.13,;6.14,-4.46,;5.37,-5.8,;3.83,-5.8,;3.06,-4.46,;3.83,-3.13,;3.35,-1.66,;6.14,-7.13,;5.37,-8.46,;7.68,-7.13,;6.91,-8.46,;.98,3.38,)| | ||
Structure |