Reaction Details | |||
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Target | Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | ||
Ligand | BDBM244795 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Biological Assay | ||
IC50 | 0.62±n/a nM | ||
Citation | Klaus, C; Raimondi, MA; Daigle, SR; Pollock, RM Combination therapy for treating cancer US Patent US9446064 Publication Date 9/20/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | |||
Name: | Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | ||
Synonyms: | DOT1L | DOT1L_HUMAN | Histone H3-K79 methyltransferase (DOT1L) | KIAA1814 | KMT4 | ||
Type: | Protein | ||
Mol. Mass.: | 47443.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q8TEK3 aa 1-416 | ||
Residue: | 416 | ||
Sequence: |
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BDBM244795 | |||
n/a | |||
Name | BDBM244795 | ||
Synonyms: | US9446064, A86 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H39N7O3 | ||
Mol. Mass. | 533.6651 | ||
SMILES | CN(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)[C@@H]1C[C@H](CCc2nc3cc(ccc3[nH]2)C(C)(C)C)C1 |r,wU:5.10,3.2,wD:22.25,20.22,6.6,8.9,(-2.45,-1.08,;-2.84,.41,;-4.18,1.18,;-5.51,.41,;-5.51,-1.13,;-6.98,-1.6,;-7.88,-.36,;-9.42,-.36,;-6.98,.89,;-7.75,2.22,;-7.75,-2.94,;-6.84,-4.18,;-7.75,-5.43,;-9.21,-4.95,;-10.55,-5.72,;-10.55,-7.26,;-11.88,-4.95,;-11.88,-3.41,;-10.55,-2.64,;-9.21,-3.41,;-1.51,1.18,;-1.11,2.67,;.38,2.27,;1.71,3.04,;3.04,2.27,;4.38,3.04,;5.84,2.56,;6.75,3.81,;8.28,3.97,;8.9,5.38,;8,6.62,;6.47,6.46,;5.84,5.06,;4.38,4.58,;10.39,5.78,;11.48,4.69,;10.79,7.26,;11.88,6.18,;-.02,.78,)| | ||
Structure |