Reaction Details | |||
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Target | Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | ||
Ligand | BDBM244797 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Biological Assay | ||
IC50 | 2.18±n/a nM | ||
Citation | Klaus, C; Raimondi, MA; Daigle, SR; Pollock, RM Combination therapy for treating cancer US Patent US9446064 Publication Date 9/20/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | |||
Name: | Histone-lysine N-methyltransferase, H3 lysine-79 specific [1-416] | ||
Synonyms: | DOT1L | DOT1L_HUMAN | Histone H3-K79 methyltransferase (DOT1L) | KIAA1814 | KMT4 | ||
Type: | Protein | ||
Mol. Mass.: | 47443.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q8TEK3 aa 1-416 | ||
Residue: | 416 | ||
Sequence: |
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BDBM244797 | |||
n/a | |||
Name | BDBM244797 | ||
Synonyms: | US9446064, A91 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H32F3N8O4 | ||
Mol. Mass. | 589.5894 | ||
SMILES | CC(C)N(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@@H]1C[C@H](CCc2nc3ccc(OC(F)(F)F)cc3n2)C1 |r,wU:8.8,10.11,wD:7.12,5.4,22.24,24.27,(.8,-8.12,;1.2,-6.63,;2.69,-6.23,;.11,-5.54,;-1.11,-6.25,;-2.33,-5.54,;-2.33,-4.13,;-3.67,-3.69,;-4.5,-4.84,;-5.91,-4.84,;-3.67,-5.98,;-4.38,-7.2,;-4.38,-2.47,;-3.55,-1.33,;-4.38,-.19,;-5.72,-.63,;-6.94,.08,;-6.94,1.49,;-8.16,-.63,;-8.16,-2.04,;-6.94,-2.74,;-5.72,-2.04,;.48,-4.18,;-.29,-2.84,;1.04,-2.07,;1.44,-.59,;2.93,-.19,;3.33,1.3,;2.08,2.21,;2.56,3.67,;1.79,5,;2.56,6.34,;4.1,6.34,;5.18,7.43,;6.67,7.03,;7.07,5.54,;7.76,8.12,;8.16,6.63,;4.87,5,;4.1,3.67,;4.57,2.21,;1.81,-3.41,)| | ||
Structure |