| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM246305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | [125I]DOI Radioligand Binding Assay. |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 4.6±n/a nM |
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| Comments | extracted |
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| Citation |  Xiong, Y; Cherrier, MC; Choi, JS; Dosa, PI; Smith, BM; Strah-Pleynet, S; Ullman, B; Teegarden, B Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto US Patent US9434692 Publication Date 9/6/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A |
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| Type: | undefined |
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| Mol. Mass.: | 52607.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28223 |
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| Residue: | 471 |
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| Sequence: | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
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| BDBM246305 |
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| n/a |
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| Name | BDBM246305 |
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| Synonyms: | US9434692, 52 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18BrFN4O2 |
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| Mol. Mass. | 409.253 |
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| SMILES | Cc1[nH]nc(C(=O)N2CCN(CC(=O)c3ccc(F)cc3)CC2)c1Br |
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| Structure | 
|
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