| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Ligand | BDBM50434349 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HotSpot Technology Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 18.78±n/a nM |
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| Comments | extracted |
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| Citation |  Leblond, B; Casagrande, A; Desire, L; Foucourt, A; Besson, T DYRK1 inhibitors and uses thereof US Patent US9446044 Publication Date 9/20/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
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| Type: | Enzyme |
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| Mol. Mass.: | 69222.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y463 |
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| Residue: | 629 |
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| Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
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| BDBM50434349 |
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| n/a |
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| Name | BDBM50434349 |
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| Synonyms: | CHEMBL2386751 | US9446044, 75 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClN5OS |
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| Mol. Mass. | 369.828 |
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| SMILES | COC(=N)c1nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2s1 |
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| Structure | 
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