Reaction Details |
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Target | Carbonic anhydrase 9 |
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Ligand | BDBM50334349 |
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Substrate/Competitor | n/a |
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Meas. Tech. | CO2 Hydration Assay |
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Ki | 0.9±0.0 nM |
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Citation | Pan, J; Lau, J; Mesak, F; Hundal, N; Pourghiasian, M; Liu, Z; Bénard, F; Dedhar, S; Supuran, CT; Lin, KS Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography. J Enzyme Inhib Med Chem29:249-55 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 9 |
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Name: | Carbonic anhydrase 9 |
Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
Type: | Enzyme |
Mol. Mass.: | 49669.03 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 459 |
Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
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BDBM50334349 |
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n/a |
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Name | BDBM50334349 |
Synonyms: | 4-(3-(3-nitrophenyl)ureido)benzenesulfonamide | 4-{[(3'-Nitrophenyl)carbamoyl]amino}benzenesulfonamide | 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide | CA IX inhibitor, (C)1 | CHEMBL1614844 |
Type | Small organic molecule |
Emp. Form. | C13H12N4O5S |
Mol. Mass. | 336.323 |
SMILES | NS(=O)(=O)c1ccc(NC(=O)Nc2cccc(c2)[N+]([O-])=O)cc1 |
Structure |
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