| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic |
|---|
| Ligand | BDBM247860 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | LC-MS Detection of 2-HG Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | <2.29±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, J; Wang, Y; Zhao, Q 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH US Patent US9434719 Publication Date 9/6/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isocitrate dehydrogenase [NADP] cytoplasmic |
|---|
| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic |
|---|
| Synonyms: | Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46661.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75874 |
|---|
| Residue: | 414 |
|---|
| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
|
|
|
|---|
| BDBM247860 |
|---|
| n/a |
|---|
| Name | BDBM247860 |
|---|
| Synonyms: | US9434719, 467 | US9688672, Example 467 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19F5N6O2 |
|---|
| Mol. Mass. | 494.4173 |
|---|
| SMILES | C[C@H](F)C1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
