| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM247971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 46±n/a nM |
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| IC50 | 53.6±n/a nM |
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| Comments | extracted |
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| Citation |  Bilcer, GM; Ng, R Quinuclidines for modulating alpha 7 activity US Patent US9434724 Publication Date 9/6/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56502.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q05941 |
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| Residue: | 502 |
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| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM247971 |
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| n/a |
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| Name | BDBM247971 |
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| Synonyms: | US9434724, 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19BrN2O3 |
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| Mol. Mass. | 379.248 |
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| SMILES | Oc1cc(Br)c2c(c[nH]c2c1)C(=O)OCC12CCN(CC1)CC2 |
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| Structure | 
|
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