Ki Summary

Reaction Details

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Target

Histamine receptor H3

Ligand

BDBM247453

Substrate/Competitor

n/a

Meas. Tech.

Radioligand Binding Assay

6.10±n/a nM

Citation

Gao, Z Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof US Patent US9453023 Publication Date 9/27/2016

More Info.:

Get all data from this article, Assay Method

Histamine receptor H3

Name:

Histamine receptor H3

Synonyms:

n/a

Type:

Enzyme

Mol. Mass.:

48611.84

Organism:

Macaca mulatta (Rhesus macaque)

Description:

Q865E1

Residue:

445

Sequence:

MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK

BDBM247453

n/a

Name

BDBM247453

Synonyms:

US9453023, 12

Type

Small organic molecule

Emp. Form.

C25H36N2O2

Mol. Mass.

396.5655

SMILES

C[C@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCC2(CCOCC2)C1=O |r,wU:9.13,wD:6.6,1.0,(6.5,-3.36,;7.27,-2.02,;8.74,-1.55,;8.74,-.01,;7.27,.47,;6.37,-.78,;4.83,-.78,;4.06,.56,;2.52,.56,;1.75,-.78,;2.52,-2.11,;4.06,-2.11,;.21,-.78,;-.56,-2.11,;-2.1,-2.11,;-2.87,-.78,;-2.1,.56,;-.56,.56,;-4.41,-.78,;-5.66,-1.68,;-6.9,-.78,;-6.43,.69,;-5.66,2.02,;-6.43,3.36,;-7.97,3.36,;-8.74,2.02,;-7.97,.69,;-4.89,.69,;-4.12,2.02,)|

Structure