| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential M8 protein |
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| Ligand | BDBM248389 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Functional Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 0.9±n/a nM |
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| Comments | extracted |
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| Citation |  Branum, ST; Colburn, RW; Dax, SL; Flores, CM; Jetter, MC; Liu, Y; Ludovici, D; Macielag, MJ; Matthews, JM; McNally, JJ; Andraka, LM; Russell, RK; Qin, N; Teleha, C; Wells, KM; Youells, SC; Youngman, MA Sulfonamides as TRPM8 modulators US Patent US9434711 Publication Date 9/6/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential M8 protein |
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| Name: | Transient receptor potential M8 protein |
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| Synonyms: | Cold-menthol receptor (TRPM8) | TRPM8 Receptor | Transient receptor potential M8 protein | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential melastatin subfamily, type 8 (TRPM8) |
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| Type: | Enzyme |
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| Mol. Mass.: | 127589.43 |
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| Organism: | Canis lupus familiaris (Dog) |
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| Description: | Q1A7N1 |
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| Residue: | 1104 |
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| Sequence: | MSFEGARLSMRNRRNGTLDSTRTLYSSTSRSTDVSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHIEGTQINSNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLLRNCDAEGYFSAQY
IMDDFKRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGRETLKAINTSIKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSVVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLANEEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTNDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
SSRDDIDVELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPIDKH
KKILWYYVAFFTSPFVVFAWNVVFYIAFLLLFAYVLLMDFHSVPHSPELVLYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHPSNKTSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEHRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFGCCCREKHAEPSACCFRNEDNETLAWEGVMKENYLVKINTKANDTSQEMRH
RFRQLDTKINDLKGLLKEIANKIK
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| BDBM248389 |
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| n/a |
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| Name | BDBM248389 |
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| Synonyms: | US9434711, 249 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26BrNO2S2 |
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| Mol. Mass. | 516.513 |
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| SMILES | Brc1c(sc2ccccc12)N(CC12CC3CC(CC(C3)C1)C2)S(=O)(=O)c1ccccc1 |TLB:15:16:20:14.19.13,19:14:21:18.20.17,19:18:21:15.14.13,THB:15:14:20:21.16.17| |
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| Structure | 
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