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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
LigandBDBM6631
Substrate/CompetitorG1 peptide
Meas. Tech.Tyrosine Kinase Assay
IC50 210±n/a nM
Citation Honma, TYoshizumi, THashimoto, NHayashi, KKawanishi, NFukasawa, KTakaki, TIkeura, CIkuta, MSuzuki-Takahashi, IHayama, TNishimura, SMorishima, H A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues. J Med Chem44:4628-40 (2001) [PubMed]  Article
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
Name:Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
Synonyms:CDK4/Cyclin D | Cyclin-Dependent Kinase 4 (CDK4)
Type:Protein Complex
Mol. Mass.:n/a
Description:CDK4/D complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components.
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 4
Synonyms:CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:Enzyme Subunit
Mol. Mass.:33731.96
Organism:Homo sapiens (Human)
Description:P11802
Residue:303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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Component 2
Name:G1/S-specific cyclin-D1 [L188C]
Synonyms:BCL1 | CCND1 | CCND1_HUMAN | Cyclin D | PRAD1
Type:Enzyme Subunit
Mol. Mass.:33634.57
Organism:Homo sapiens (Human)
Description:P24385[L188C]
Residue:295
Sequence:
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDGSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVASCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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BDBM6631
G1 peptide
Name:G1 peptide
Synonyms:n/a
Type:Peptide
Mol. Mass.:1483.28
Organism:n/a
Description:n/a
Residue:13
Sequence:
RPPTLSPIPHIPR