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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [368-440] | ||
| Ligand | BDBM249276 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 69.2±n/a nM | ||
| Comments | extracted | ||
| Citation |  Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [368-440] | |||
| Name: | Bromodomain-containing protein 4 [368-440] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 8564.63 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD2 (368-440 aa) of O60885 | ||
| Residue: | 73 | ||
| Sequence: |
| ||
| BDBM249276 | |||
| n/a | |||
| Name | BDBM249276 | ||
| Synonyms: | US10017501, Compound 1020-12 | US9458145, 1020-12 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21N5O | ||
| Mol. Mass. | 347.4136 | ||
| SMILES | Cc1cnn(C)c1-c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C |(.79,-3.53,;2.13,-2.76,;3.59,-3.24,;4.5,-1.99,;3.59,-.75,;4.36,.59,;2.13,-1.22,;.79,-.45,;.79,1.09,;-.54,1.86,;-1.87,1.09,;-1.87,-.45,;-3.02,-1.48,;-2.39,-2.89,;-.86,-2.73,;-.54,-1.22,;-3.16,-4.23,;-4.5,-5,;-3.16,-5.77,;-.54,3.4,;.71,4.3,;2.04,3.53,;.23,5.77,;-1.31,5.77,;-1.79,4.3,;-3.12,3.53,)| | ||
| Structure | 
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