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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [368-440] | ||
| Ligand | BDBM249287 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 64.8±n/a nM | ||
| Comments | extracted | ||
| Citation |  Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [368-440] | |||
| Name: | Bromodomain-containing protein 4 [368-440] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 8564.63 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD2 (368-440 aa) of O60885 | ||
| Residue: | 73 | ||
| Sequence: |
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| BDBM249287 | |||
| n/a | |||
| Name | BDBM249287 | ||
| Synonyms: | US10017501, Compound 1020-77 | US9458145, 1020-77 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H19N5O | ||
| Mol. Mass. | 321.3764 | ||
| SMILES | Cc1nc2cc(cc(-c3c(C)n[nH]c3C)c2[nH]1)-c1c(C)noc1C |(-3.83,-5,;-3.06,-3.66,;-3.69,-2.25,;-2.54,-1.22,;-2.54,.32,;-1.21,1.09,;.13,.32,;.13,-1.22,;1.46,-1.99,;2.92,-1.52,;3.69,-.18,;3.83,-2.76,;2.92,-4.01,;1.46,-3.53,;.13,-4.3,;-1.21,-1.99,;-1.53,-3.5,;-1.21,2.63,;.04,3.53,;1.37,2.76,;-.44,5,;-1.98,5,;-2.45,3.53,;-3.79,2.76,)| | ||
| Structure | 
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