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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 [75-147] | ||
| Ligand | BDBM249285 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Amplified Luminescent Proximity Homogeneous Assay (ALPHA) | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 18.9±n/a nM | ||
| Comments | extracted | ||
| Citation |  Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 [75-147] | |||
| Name: | Bromodomain-containing protein 4 [75-147] | ||
| Synonyms: | BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1 | ||
| Type: | n/a | ||
| Mol. Mass.: | 8856.55 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD1 (75-147 aa) of O60885 | ||
| Residue: | 73 | ||
| Sequence: |
| ||
| BDBM249285 | |||
| n/a | |||
| Name | BDBM249285 | ||
| Synonyms: | US10017501, Compound 1020-74 | US9458145, 1020-74 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H24N4O | ||
| Mol. Mass. | 408.495 | ||
| SMILES | Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2n(C)c(nc2c1)C1CC1 |(-3.94,3.53,;-2.6,4.3,;-2.13,5.77,;-.59,5.77,;-.11,4.3,;1.22,3.53,;-1.36,3.4,;-1.36,1.86,;-.02,1.09,;-.02,-.45,;1.31,-1.22,;1.31,-2.76,;-.02,-3.53,;2.64,-3.53,;3.98,-2.76,;3.98,-1.22,;5.31,-.45,;5.31,1.09,;3.98,1.86,;2.64,1.09,;2.64,-.45,;-1.36,-1.22,;-1.68,-2.73,;-.59,-3.82,;-3.21,-2.89,;-3.83,-1.48,;-2.69,-.45,;-2.69,1.09,;-3.98,-4.23,;-5.31,-5,;-3.98,-5.77,)| | ||
| Structure | 
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