Reaction Details | |||
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Target | Coagulation factor XI | ||
Ligand | BDBM238256 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Factor XIa Enzyme Assay | ||
IC50 | 14.0±n/a nM | ||
Citation | Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases US Patent US9585881 Publication Date 3/7/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Coagulation factor XI | |||
Name: | Coagulation factor XI | ||
Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent | ||
Type: | Enzyme | ||
Mol. Mass.: | 70130.58 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P03951 | ||
Residue: | 625 | ||
Sequence: |
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BDBM238256 | |||
n/a | |||
Name | BDBM238256 | ||
Synonyms: | US10336741, Example 55 | US10882855, Example 55 | US9394250, 55 | US9585881, Example 55 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H39N5O6S | ||
Mol. Mass. | 561.693 | ||
SMILES | NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1 |r,wU:2.1,12.29,14.16,wD:5.8,(-7.93,-8.37,;-7.93,-6.83,;-6.6,-6.06,;-6.6,-4.52,;-5.26,-3.75,;-3.93,-4.52,;-3.93,-6.06,;-5.26,-6.83,;-2.6,-3.75,;-1.26,-4.52,;-2.6,-2.21,;-3.84,-1.3,;-3.37,.16,;-1.83,.16,;-1.35,-1.3,;-.02,-2.07,;-.02,-3.61,;1.32,-1.3,;2.65,-2.07,;3.98,-1.3,;5.32,-2.07,;5.37,-3.64,;3.98,-4.38,;2.65,-3.61,;6.7,-4.41,;6.7,-5.95,;8.03,-3.64,;-4.14,1.49,;-3.37,2.83,;-4.14,4.16,;-5.68,4.16,;-6.45,2.83,;-5.68,1.49,;-6.45,5.5,;-7.99,5.5,;-4.91,5.5,;-5.68,6.83,;-4.34,7.6,;-5.68,8.37,)| | ||
Structure |