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TargetProstaglandin D Synthase
LigandBDBM250506
Substrate/Competitorn/a
Meas. Tech.Enzyme Immunoassay (EIA) Assay
pH7.4±n/a
IC50 12±n/a nM
Commentsextracted
Citation Vandeusen CLWeiberth FJGill HSLee GHillegass A Phenyloxadiazole derivatives as PGDS inhibitors US Patent  US9469627 Publication Date 10/18/2016
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D Synthase
Name:Prostaglandin D Synthase
Synonyms:Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | Prostaglandin D
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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  Blast E-value cutoff:
BDBM250506
n/a
NameBDBM250506
Synonyms:US9469627, 1
TypeSmall organic molecule
Emp. Form.C22H20N6O3
Mol. Mass.416.4326
SMILESCC(C)(O)c1nc(no1)-c1cccc(CNC(=O)c2cnc(nc2)-c2ccccn2)c1
Structure
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