| Reaction Details |
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 | Report a problem with these data |
| Target | Hematopoietic prostaglandin D synthase |
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| Ligand | BDBM250508 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Immunoassay (EIA) Assay |
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| pH | 7.4±n/a |
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| IC50 | 26±n/a nM |
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| Comments | extracted |
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| Citation |  Vandeusen, CL; Weiberth, FJ; Gill, HS; Lee, G; Hillegass, A Phenyloxadiazole derivatives as PGDS inhibitors US Patent US9469627 Publication Date 10/18/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Hematopoietic prostaglandin D synthase |
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| Name: | Hematopoietic prostaglandin D synthase |
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| Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23341.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
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| Residue: | 199 |
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| Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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| BDBM250508 |
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| n/a |
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| Name | BDBM250508 |
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| Synonyms: | US9469627, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N6O3 |
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| Mol. Mass. | 430.4592 |
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| SMILES | C[C@@H](NC(=O)c1cnc(nc1)-c1ccccn1)c1cccc(c1)-c1noc(n1)C(C)(C)O |r| |
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| Structure | 
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