| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase |
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| Ligand | BDBM10880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158312 (CHEMBL763369) |
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| pH | 7.5±0 |
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| Temperature | 293.15±0 K |
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| Ki | 63±0 nM |
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| Km | 7000000±0 nM |
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| Citation |  Del Prete, S; Vullo, D; De Luca, V; Carginale, V; di Fonzo, P; Osman, SM; AlOthman, Z; Supuran, CT; Capasso, C Anion inhibition profiles of a-, ß- and ¿-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. Bioorg Med Chem24:3413-7 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Carbonic anhydrase |
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| Name: | Carbonic anhydrase |
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| Synonyms: | CAH_METTT | CAM | Carbonic anhydrase | Gamma-carbonic anhydrase |
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| Type: | Protein |
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| Mol. Mass.: | 26390.56 |
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| Organism: | Methanosarcina thermophila |
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| Description: | P40881 |
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| Residue: | 247 |
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| Sequence: | MMFNKQIFTILILSLSLALAGSGCISEGAEDNVAQEITVDEFSNIRENPVTPWNPEPSAP
VIDPTAYIDPQASVIGEVTIGANVMVSPMASIRSDEGMPIFVGDRSNVQDGVVLHALETI
NEEGEPIEDNIVEVDGKEYAVYIGNNVSLAHQSQVHGPAAVGDDTFIGMQAFVFKSKVGN
NCVLEPRSAAIGVTIPDGRYIPAGMVVTSQAEADKLPEVTDDYAYSHTNEAVVYVNVHLA
EGYKETS
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| BDBM10880 |
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| n/a |
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| Name | BDBM10880 |
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| Synonyms: | AZA | AZA2 | AZM acetazolamide | Acerazolamide, AAZ | Acetazolamide | Acetazolamide (AAZ) | Acetazolamide (AZA) | Acetazolamide (AZM) | Acetazolamide, 5 | Acetazolamide, AAZ | Acetazolamide, AZA | Acetazolamide, AZM | CHEMBL20 | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Sulfonamide, 1 | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide | sulfonamide 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C4H6N4O3S2 |
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| Mol. Mass. | 222.245 |
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| SMILES | CC(=O)Nc1nnc(s1)S(N)(=O)=O |
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| Structure | 
|
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