| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase mTOR [1360-2549] |
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| Ligand | BDBM251615 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LanthaScreen Kinase Activity Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 275±n/a nM |
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| Comments | extracted |
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| Citation |  Pastor Fernández, J; Fernández-Capetillo Ruiz, O; Martínez González, S; Blanco Aparicio, C; Rico Ferreira, M; Toledo Lázaro, LI; Rodríguez Arísteguí, S; Murga Costa, M; Varela Busto, C; Lopez Contreras, AJ; Renner, O; Nieto Soler, M; Cebrián Muñoz, DA Chemical entities US Patent US9453031 Publication Date 9/27/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Serine/threonine-protein kinase mTOR [1360-2549] |
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| Name: | Serine/threonine-protein kinase mTOR [1360-2549] |
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| Synonyms: | FRAP | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | RAFT1 | RAPT1 | Serine/threonine-protein kinase mTOR |
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| Type: | Enzyme |
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| Mol. Mass.: | 136306.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1360-2549 |
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| Residue: | 1190 |
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| Sequence: | LAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISI
NNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLG
RMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRD
THDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSEL
EEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASL
CGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQH
FVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAA
TEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATAT
TTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNN
LQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQ
LLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRV
AILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLM
EAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELA
VPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVM
QLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKI
LLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTN
YTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRL
TRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGN
KRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQ
IINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
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| BDBM251615 |
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| n/a |
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| Name | BDBM251615 |
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| Synonyms: | US9453031, 38 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O3 |
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| Mol. Mass. | 366.4137 |
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| SMILES | CC(C)(O)c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12 |
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| Structure | 
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