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TargetApoptosis regulator Bcl-2/Glutathione S-transferase P
LigandBDBM185621
Substrate/Competitorn/a
Meas. Tech.Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Temperature298.15±n/a K
Ki 437.92±n/a nM
Commentsextracted
Citation Kunzer, ARElmore, SWSullivan, GM Apoptosis-inducing agent for the treatment of cancer and immune and autoimmune diseases US Patent US9493431 Publication Date 11/15/2016
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2/Glutathione S-transferase P
Name:Apoptosis regulator Bcl-2/Glutathione S-transferase P
Synonyms:GST-Bcl-2 Protein
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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Component 2
Name:Glutathione S-transferase P
Synonyms:FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:Enzyme
Mol. Mass.:23353.53
Organism:Homo sapiens (Human)
Description:P09211
Residue:210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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BDBM185621
n/a
NameBDBM185621
Synonyms:US9156856, 32 | US9493431, 32
TypeSmall organic molecule
Emp. Form.C29H29ClN4O4S
Mol. Mass.565.083
SMILESCc1noc(C)c1S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1
Structure
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