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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Amine oxidase [flavin-containing] A | ||
| Ligand | BDBM254553 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence-Based (Inhibitor)-Screening Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 310.15±n/a K | ||
| Ki | 20000±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martínez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9469597 Publication Date 10/18/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Amine oxidase [flavin-containing] A | |||
| Name: | Amine oxidase [flavin-containing] A | ||
| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) | ||
| Type: | Protein | ||
| Mol. Mass.: | 59689.53 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21397 | ||
| Residue: | 527 | ||
| Sequence: |
| ||
| BDBM254553 | |||
| n/a | |||
| Name | BDBM254553 | ||
| Synonyms: | US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-(trifluoromethyl)phenyl)pyridin-3-yl)cyclopropyl)amino)cyclohexanecarboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24F3N3O | ||
| Mol. Mass. | 403.4407 | ||
| SMILES | NC(=O)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F |r,wU:12.14,wD:10.10,(8.88,3.85,;7.54,4.62,;7.54,6.16,;6.21,3.85,;6.21,2.31,;4.87,1.54,;3.54,2.31,;3.54,3.85,;4.87,4.62,;2.21,1.54,;.87,2.31,;.1,3.64,;-.67,2.31,;-2,1.54,;-3.33,2.31,;-4.67,1.54,;-4.67,,;-3.33,-.77,;-2,,;-6,-.77,;-7.34,,;-8.67,-.77,;-8.67,-2.31,;-7.34,-3.14,;-6,-2.31,;-7.34,-4.68,;-7.34,-6.22,;-8.88,-4.68,;-5.8,-4.68,)| | ||
| Structure | 
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