Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM255023 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
IC50 | 2.4±n/a nM | ||
Citation | Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM255023 | |||
n/a | |||
Name | BDBM255023 | ||
Synonyms: | US9475813, 28 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H26F3N5O | ||
Mol. Mass. | 421.4592 | ||
SMILES | FC(F)(F)CNC[C@H]1CC[C@@H](CC1)N1CN(C2CC2)C(=O)c2cnc3[nH]ccc3c12 |r,wU:10.13,wD:7.6,(-.87,9.06,;.67,9.01,;.71,10.55,;.62,7.47,;2.21,8.96,;2.93,7.6,;4.47,7.56,;5.2,6.2,;4.39,4.89,;5.12,3.53,;6.66,3.48,;7.47,4.79,;6.74,6.15,;7.38,2.13,;8.92,2.08,;9.65,.72,;11.19,.67,;12.55,1.4,;12.5,-.14,;8.84,-.59,;9.57,-1.94,;7.3,-.54,;6.49,-1.85,;4.95,-1.8,;4.22,-.44,;2.73,-.08,;2.61,1.46,;4.04,2.04,;5.03,.87,;6.57,.82,)| | ||
Structure |