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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM254980 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 0.42±n/a nM | ||
| Citation |  Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM254980 | |||
| n/a | |||
| Name | BDBM254980 | ||
| Synonyms: | US9475813, 36 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24F3N5O3S | ||
| Mol. Mass. | 459.486 | ||
| SMILES | CN1CN([C@H]2CC[C@H](CNS(=O)(=O)CC(F)(F)F)CC2)c2c(cnc3[nH]ccc23)C1=O |r,wU:4.3,wD:7.7,(-8,.87,;-6.67,.1,;-5.33,.87,;-4,.1,;-2.67,.87,;-2.67,2.41,;-1.33,3.18,;,2.41,;1.33,3.18,;2.67,2.41,;4,3.18,;4.77,4.52,;3.23,4.52,;2.63,3.88,;2.55,5.42,;2.47,6.96,;4.09,5.5,;1.01,5.34,;,.87,;-1.33,.1,;-4,-1.44,;-5.33,-2.21,;-5.33,-3.75,;-4,-4.52,;-2.67,-3.75,;-1.2,-4.22,;-.3,-2.98,;-1.2,-1.73,;-2.67,-2.21,;-6.67,-1.44,;-8,-2.21,)| | ||
| Structure | 
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