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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM254988 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 1.4±n/a nM | ||
| Citation |  Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM254988 | |||
| n/a | |||
| Name | BDBM254988 | ||
| Synonyms: | US9475813, 44 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H29N5O3S | ||
| Mol. Mass. | 443.562 | ||
| SMILES | O=C1N(CN([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)c2c1cnc1[nH]ccc21)C1CC1 |r,wU:5.4,wD:8.8,(-5.76,-2.06,;-4.42,-1.29,;-4.42,.25,;-3.09,1.02,;-1.76,.25,;-.42,1.02,;-.42,2.56,;.91,3.33,;2.24,2.56,;3.58,3.33,;4.91,2.56,;4.93,1.02,;6.39,.54,;7.3,1.79,;6.39,3.04,;7.16,4.37,;5.62,4.37,;2.24,1.02,;.91,.25,;-1.76,-1.29,;-3.09,-2.06,;-3.09,-3.6,;-1.76,-4.37,;-.42,-3.6,;1.04,-4.08,;1.95,-2.83,;1.04,-1.58,;-.42,-2.06,;-5.76,1.02,;-6.53,2.35,;-7.3,1.02,)| | ||
| Structure | 
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