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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM254997 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 2.6±n/a nM | ||
| Citation |  Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM254997 | |||
| n/a | |||
| Name | BDBM254997 | ||
| Synonyms: | US9475813, 67 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H26F3N5O3S | ||
| Mol. Mass. | 485.523 | ||
| SMILES | FC(F)(F)CN1CN([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O |r,wU:8.7,wD:11.11,(-8.68,.66,;-7.19,.26,;-7.59,-1.23,;-5.86,-.51,;-5.86,1.03,;-4.52,.26,;-3.19,1.03,;-1.86,.26,;-.52,1.03,;-.52,2.57,;.81,3.34,;2.15,2.57,;3.48,3.34,;4.81,2.57,;4.81,1.03,;6.27,.54,;7.19,1.77,;6.27,3.03,;5.5,4.36,;7.04,4.36,;2.15,1.03,;.81,.26,;-1.86,-1.28,;-3.19,-2.05,;-3.19,-3.59,;-1.86,-4.36,;-.52,-3.59,;.94,-4.07,;1.85,-2.82,;.94,-1.58,;-.52,-2.05,;-4.52,-1.28,;-5.86,-2.05,)| | ||
| Structure | 
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