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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM254982 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | 0.62±n/a nM | ||
| Citation |  Takahashi, K; Watanabe, T; Hayashi, K; Kurihara, K; Nakamura, T; Yamamoto, A; Nishimura, T; Kamiyama, T; Hidaka, Y Tricyclic pyrrolopyridine compound, and JAK inhibitor US Patent US9475813 Publication Date 10/25/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM254982 | |||
| n/a | |||
| Name | BDBM254982 | ||
| Synonyms: | US9475813, 38 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H27N5O3S | ||
| Mol. Mass. | 417.525 | ||
| SMILES | CN1CN([C@H]2CC[C@H](CN3CCCS3(=O)=O)CC2)c2c(cnc3[nH]ccc23)C1=O |r,wU:4.3,wD:7.7,(-6.53,1.02,;-5.19,.25,;-3.86,1.02,;-2.53,.25,;-1.19,1.02,;-1.19,2.56,;.14,3.33,;1.47,2.56,;2.81,3.33,;4.14,2.56,;4.16,1.02,;5.62,.54,;6.53,1.79,;5.62,3.04,;6.39,4.37,;4.85,4.37,;1.47,1.02,;.14,.25,;-2.53,-1.29,;-3.86,-2.06,;-3.86,-3.6,;-2.53,-4.37,;-1.19,-3.6,;.27,-4.08,;1.18,-2.83,;.27,-1.58,;-1.19,-2.06,;-5.19,-1.29,;-6.53,-2.06,)| | ||
| Structure | 
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