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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM255466 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) Assay | ||
| IC50 | 0.17±n/a nM | ||
| Citation |  Kim, RM; Liu, J; Gao, X; Boga, SB; Guiadeen, D; Kozlowski, JA; Yu, W; Anand, R; Yu, Y; Selyutin, OB; Gao, Y; Wu, H; Liu, S; Yang, C; Wang, H Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors US Patent US9481682 Publication Date 11/1/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
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| BDBM255466 | |||
| n/a | |||
| Name | BDBM255466 | ||
| Synonyms: | US9481682, 217 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H24ClF4N7O3 | ||
| Mol. Mass. | 617.982 | ||
| SMILES | COc1cc(cc(F)c1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12)C(=O)Nc1cc(ccn1)C(F)(F)F |r,wU:12.12,wD:15.21,(2.36,-.45,;.87,-.84,;-.22,.25,;.18,1.73,;-.91,2.82,;-2.4,2.42,;-2.8,.94,;-4.28,1.33,;-1.71,-.15,;-2.1,-1.64,;-1.2,-2.89,;-2.1,-4.13,;-1.71,-5.62,;-2.8,-6.71,;-2.4,-8.2,;-.91,-8.6,;-.21,-9.97,;1.31,-9.73,;1.55,-8.21,;2.89,-7.44,;.18,-7.51,;-.22,-6.02,;-3.57,-3.66,;-4.9,-4.43,;-4.9,-5.97,;-6.24,-3.66,;-6.24,-2.12,;-4.9,-1.35,;-4.9,.19,;-3.57,-2.12,;-.51,4.31,;-1.6,5.4,;.98,4.71,;1.38,6.2,;2.86,6.59,;3.26,8.08,;2.17,9.17,;.69,8.77,;.29,7.28,;4.75,8.48,;5.84,7.39,;6.24,8.88,;5.15,9.97,)| | ||
| Structure | 
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