| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM294228 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| Ki | <10.00±n/a nM |
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| Citation |  Amberg, W; Pohlki, F; Lange, U; Wang, Y; Brewer, J; Vasudevan, A; Lao, Y; Hutchins, C; Zhao, H; Li, H Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent US9586942 Publication Date 3/7/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Name: | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50891.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107587 |
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| Residue: | 445 |
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| Sequence: | MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQD
AEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRR
CLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQ
GYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSA
WNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQG
RACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLA
RVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIV
TFQFRGRRVHLAPPLTWEGYDPSWN
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| BDBM294228 |
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| n/a |
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| Name | BDBM294228 |
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| Synonyms: | N-(1-((7S,8R)-7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)azetidin-3-yl)-1-methyl-1H-pyrazole-4-sulfonamide | US9586942, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33N5O2S |
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| Mol. Mass. | 491.648 |
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| SMILES | Cn1cnc(c1)S(=O)(=O)NC1CN(C1)c1ccc2CC[C@@H]([C@H](Cc3ccccc3)c2c1)N1CCC1 |r| |
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| Structure | 
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