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TargetTyrosine-protein kinase SYK
LigandBDBM255501
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 37.8±n/a nM
Commentsextracted
Citation Singh, RArgade, APayan, DGMolineaux, SHolland, SJClough, JKeim, HBhamidipati, SSylvain, CLi, HRossi, AB 2,4-pyrimidinediamine compounds and their uses US Patent US9499493 Publication Date 11/22/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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  Blast E-value cutoff:
BDBM255501
n/a
NameBDBM255501
Synonyms:US9499493, R908702
TypeSmall organic molecule
Emp. Form.C18H14FN5O3
Mol. Mass.367.3339
SMILESOc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4c3)n2)c1
Structure
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