Reaction Details |
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Target | chymase |
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Ligand | BDBM255927 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Chymase Assay |
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pH | 7.5±n/a |
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IC50 | 2±n/a nM |
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Comments | extracted |
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Citation | Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M; Börngen, K Bicyclically substituted uracils and the use thereof US Patent US9481672 Publication Date 11/1/2016 |
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More Info.: | Get all data from this article, Assay Method |
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chymase |
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Name: | chymase |
Synonyms: | n/a |
Type: | Enzyme |
Mol. Mass.: | 27507.42 |
Organism: | Mesocricetus auratus (Golden hamster) |
Description: | A0A1U7QTH6 |
Residue: | 247 |
Sequence: | MLLPALRLLLFLLGSSAEAGKIIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNF
VMTAAHCAGRSITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDHLVLNDIMLLKLKEKA
NLTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILDPQACKHFED
FHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVLRNAKPPSVFTRISHYRPWI
NKILREN
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BDBM255927 |
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n/a |
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Name | BDBM255927 |
Synonyms: | US9481672, 104 |
Type | Small organic molecule |
Emp. Form. | C26H22F4N4O5 |
Mol. Mass. | 546.4703 |
SMILES | CCOC(=O)c1cn(-c2cc3n(C)c(=O)n(C)c3cc2F)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O |r| |
Structure |
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