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TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)
LigandBDBM256343
Substrate/Competitorn/a
Meas. Tech.TR-FRET Assay
pH7±n/a
Temperature277.15±n/a K
IC50 182±n/a nM
Commentsextracted
Citation Barr, KJMaclean, JKZhang, HBeresis, RTZhang, DAndresen, BMAnthony, NJLapointe, BTSciammetta, N 3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof US Patent US9487490 Publication Date 11/8/2016
More Info.:Get all data from this article,  Assay Method
 
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
Name:Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
Synonyms:Isoform 2 of Nuclear receptor ROR-gamma | NR1F3 | Nuclear receptor ROR-gamma (RORgT) | Nuclear receptor ROR-gammaT | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma (RORgT) | Retinoid-related orphan receptor-gamma (RORĪ³T)
Type:Protein
Mol. Mass.:55831.73
Organism:Homo sapiens (Human)
Description:P51449-2
Residue:497
Sequence:
MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK
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  Blast E-value cutoff:
BDBM256343
n/a
NameBDBM256343
Synonyms:US9487490, 1G
TypeSmall organic molecule
Emp. Form.C22H17ClF3N3O3
Mol. Mass.463.837
SMILESCC1C=C(CCC1C(O)=O)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccnc12 |c:2|
Structure
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