Reaction Details |
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Target | Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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Ligand | BDBM256350 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TR-FRET Assay |
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pH | 7±n/a |
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Temperature | 277.15±n/a K |
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IC50 | 4±n/a nM |
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Comments | extracted |
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Citation | Barr, KJ; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Andresen, BM; Anthony, NJ; Lapointe, BT; Sciammetta, N 3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof US Patent US9487490 Publication Date 11/8/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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Name: | Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
Synonyms: | Isoform 2 of Nuclear receptor ROR-gamma | NR1F3 | Nuclear receptor ROR-gamma (RORgT) | Nuclear receptor ROR-gammaT | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma (RORgT) | Retinoid-related orphan receptor-gamma (RORĪ³T) |
Type: | Protein |
Mol. Mass.: | 55831.73 |
Organism: | Homo sapiens (Human) |
Description: | P51449-2 |
Residue: | 497 |
Sequence: | MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK
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BDBM256350 |
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n/a |
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Name | BDBM256350 |
Synonyms: | US9487490, 2C |
Type | Small organic molecule |
Emp. Form. | C30H30ClN3O5 |
Mol. Mass. | 548.029 |
SMILES | COC1CN(C1)C(=O)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C3CC3)c2c1)C1=CC[C@@](C)(CC1)C(O)=O |r,t:34| |
Structure |
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