Ki Summary

Reaction Details

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Target

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Ligand

BDBM256385

Substrate/Competitor

n/a

Meas. Tech.

TR-FRET Assay

7±n/a

Temperature

277.15±n/a K

IC50

16±n/a nM

Comments

extracted

Citation

Barr, KJ; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Andresen, BM; Anthony, NJ; Lapointe, BT; Sciammetta, N 3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof US Patent US9487490 Publication Date 11/8/2016

More Info.:

Get all data from this article, Assay Method

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Name:

Isoform 2 of Nuclear receptor ROR-gamma (RORgT)

Synonyms:

Type:

Protein

Mol. Mass.:

55831.73

Organism:

Homo sapiens (Human)

Description:

P51449-2

Residue:

497

Sequence:

MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK

BDBM256385

n/a

Name

BDBM256385

Synonyms:

US9487490, 8A

Type

Small organic molecule

Emp. Form.

C22H17ClF4N2O3

Mol. Mass.

468.829

SMILES

OC(=O)[C@H]1CC[C@@H](CC1)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12 |r,wU:6.9,wD:3.2,(-2.81,9.19,;-1.72,8.1,;-.23,8.5,;-2.12,6.61,;-3.62,6.16,;-4.02,4.67,;-2.93,3.59,;-1.44,3.98,;-1.04,5.47,;-3.33,2.1,;-2.42,.85,;-3.33,-.39,;-2.93,-1.88,;-4.02,-2.97,;-1.44,-2.28,;-.35,-1.19,;-.75,.3,;1.13,-1.59,;1.53,-3.08,;.44,-4.17,;-1.04,-3.77,;-2.13,-4.86,;-3.67,-4.86,;-3.22,-5.95,;-1.74,-6.34,;-4.79,.08,;-6.13,-.69,;-7.46,.08,;-7.46,1.62,;-6.13,2.39,;-6.13,3.93,;-4.79,1.62,)|

Structure