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TargetGST-Lysine-specific histone demethylase 1A (LSD1)
LigandBDBM256461
Substrate/Competitorn/a
Meas. Tech.Biological Assay
pH7.4±n/a
Temperature310.15±n/a K
Ki 50±n/a nM
Commentsextracted
Citation Ortega Muñoz AFyfe MCMartinell Pedemonte MEstiarte Martinez MValls Vidal NKurz GCastro Palomino Laria JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent  US9487512 Publication Date 11/8/2016
More Info.:Get all data from this article,  Assay Method
 
GST-Lysine-specific histone demethylase 1A (LSD1)
Name:GST-Lysine-specific histone demethylase 1A (LSD1)
Synonyms:n/a
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Glutathione S-transferase Pi
Synonyms:GST class-pi | GSTP1-1 | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P
Type:Enzyme
Mol. Mass.:23353.53
Organism:Homo sapiens (Human)
Description:P09211
Residue:210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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Component 2
Name:Lysine-specific histone demethylase 1A (LSD1)
Synonyms:n/a
Type:n/a
Mol. Mass.:79318.93
Organism:Homo sapiens (Human)
Description:amino acids 158-end; GenBank accession no. NM_015013, uniprot: O60341-2 from NM_015013
Residue:718
Sequence:
PPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPD
IISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLER
HGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVA
TFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKEK
DEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKI
VKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEY
DELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQ
DDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTF
IYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS
VNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGI
FGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIP
RLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
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BDBM256461
n/a
NameBDBM256461
Synonyms:US9487512, 6
TypeSmall organic molecule
Emp. Form.C16H24N2
Mol. Mass.244.3752
SMILESC(CC1CCNCC1)N[C@H]1C[C@@H]1c1ccccc1 |r|
Structure
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