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TargetGlutathione S-transferase P/Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876]
LigandBDBM256462
Substrate/Competitorn/a
Meas. Tech.Biological Assay
pH7.4±n/a
Temperature310.15±n/a K
Ki 550±n/a nM
Commentsextracted
Citation Ortega Muñoz, AFyfe, MCMartinell Pedemonte, MEstiarte Martinez, MValls Vidal, NKurz, GCastro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9487512 Publication Date 11/8/2016
More Info.:Get all data from this article,  Assay Method
 
Glutathione S-transferase P/Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876]
Name:Glutathione S-transferase P/Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876]
Synonyms:GST-Lysine-specific histone demethylase 1A (LSD1) | Glutathione S-transferase P/Lysine-specific histone demethylase 1A (2) [158-876]
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Glutathione S-transferase P
Synonyms:FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:Enzyme
Mol. Mass.:23353.53
Organism:Homo sapiens (Human)
Description:P09211
Residue:210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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Component 2
Name:Isoform 2 of Lysine-specific histone demethylase 1A (2) [158-876]
Synonyms:AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A (2) [158-876] | Lysine-specific histone demethylase 1A (LSD1)
Type:n/a
Mol. Mass.:79390.01
Organism:Homo sapiens (Human)
Description:amino acids 158-end; GenBank accession no. NM_015013, uniprot: O60341-2 from NM_015013
Residue:719
Sequence:
APPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFP
DIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLE
RHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRV
ATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKE
KDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKK
IVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKE
YDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD
QDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQT
FIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDP
SVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKG
IFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPI
PRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
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BDBM256462
n/a
NameBDBM256462
Synonyms:US10329256, Example 7 | US9487512, 7 | US9944601, Example 7
TypeSmall organic molecule
Emp. Form.C20H21F3N2O
Mol. Mass.362.3887
SMILESFC(F)(F)c1cccc(c1)-c1ccc(cn1)[C@H]1C[C@@H]1NC1CCOCC1 |r|
Structure
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