| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [172-833] |
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| Ligand | BDBM256652 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Activity Assay |
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| pH | 8±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <100±n/a nM |
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| Comments | extracted |
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| Citation |  Matsumoto, S; Hattori, Y; Toyofuku, M; Morimoto, S; Daini, M; Kojima, T; Kaku, T; Ito, M Cyclopropanamine compound and use thereof US Patent US9487511 Publication Date 11/8/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Glutathione S-transferase P/Lysine-specific histone demethylase 1A [172-833] |
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| Name: | Glutathione S-transferase P/Lysine-specific histone demethylase 1A [172-833] |
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| Synonyms: | GST-Lysine-specific histone demethylase 1A (LSD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glutathione S-transferase P |
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| Synonyms: | FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST) |
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| Type: | Enzyme |
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| Mol. Mass.: | 23353.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09211 |
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| Residue: | 210 |
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| Sequence: | MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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| Component 2 |
| Name: | Lysine-specific histone demethylase 1A [172-833] |
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| Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A (LSD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 73571.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 172-833 |
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| Residue: | 662 |
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| Sequence: | SGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTF
EATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGL
AAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNM
ELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQA
LEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPP
RDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDW
HFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVR
QVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAV
QRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEA
AGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGN
DYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLG
AM
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| BDBM256652 |
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| n/a |
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| Name | BDBM256652 |
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| Synonyms: | US10053456, 31 | US10414761, Example 31 | US10968213, Example 31 | US9487511, 31 | US9718814, 31 | US9920047, 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26F2N2O2S |
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| Mol. Mass. | 384.484 |
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| SMILES | FC1(F)CCC(CC1)NC(=O)c1csc(c1)C1CC1NC1CCOCC1 |
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| Structure | 
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