Reaction Details |
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Target | Histone deacetylase 4 [648-729,745-1057] |
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Ligand | BDBM257503 |
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Substrate/Competitor | US9505736, Boc-Lys(Tfa)-AMC |
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Meas. Tech. | Biochemical Assay |
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pH | 8±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 20±n/a nM |
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Comments | extracted |
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Citation | Dominguez, C; Breccia, P; Luckhurst, CA; Bürli, RW; Stott, AJ Histone deacetylase inhibitors and compositions and methods of use thereof US Patent US9505736 Publication Date 11/29/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 4 [648-729,745-1057] |
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Name: | Histone deacetylase 4 [648-729,745-1057] |
Synonyms: | HDAC4 | HDAC4_HUMAN | Histone deacetylase 4 (HDAC4) | KIAA0288 |
Type: | Enzyme |
Mol. Mass.: | 43928.30 |
Organism: | Homo sapiens (Human) |
Description: | amino acids 648-1057, replacement of amino acids 730-744 with 4 amino acid GSGS |
Residue: | 410 |
Sequence: | TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKAT
LEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHS
AGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQ
RLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVG
FNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYN
LSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQ
RPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT
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BDBM257503 |
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US9505736, Boc-Lys(Tfa)-AMC |
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Name | BDBM257503 |
Synonyms: | US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-(4-(5- methylpyrimidin-2-yl)phenyl)-3- phenylcyclopropanecarboxamide |
Type | Small organic molecule |
Emp. Form. | C21H18FN3O2 |
Mol. Mass. | 363.3849 |
SMILES | Cc1cnc(nc1)-c1ccc(cc1)[C@@H]1[C@@H](c2ccccc2)[C@@]1(F)C(=O)NO |r| |
Structure |
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