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TargetHistone deacetylase 4 [648-729,745-1057]
LigandBDBM257503
Substrate/CompetitorUS9505736, Boc-Lys(Tfa)-AMC
Meas. Tech.Biochemical Assay
pH8±n/a
Temperature298.15±n/a K
IC50 20±n/a nM
Commentsextracted
Citation Dominguez, CBreccia, PLuckhurst, CABürli, RWStott, AJ Histone deacetylase inhibitors and compositions and methods of use thereof US Patent US9505736 Publication Date 11/29/2016
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 4 [648-729,745-1057]
Name:Histone deacetylase 4 [648-729,745-1057]
Synonyms:HDAC4 | HDAC4_HUMAN | Histone deacetylase 4 (HDAC4) | KIAA0288
Type:Enzyme
Mol. Mass.:43928.30
Organism:Homo sapiens (Human)
Description:amino acids 648-1057, replacement of amino acids 730-744 with 4 amino acid GSGS
Residue:410
Sequence:
TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKAT
LEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHS
AGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQ
RLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVG
FNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYN
LSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQ
RPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT
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  Blast E-value cutoff:
BDBM257503
US9505736, Boc-Lys(Tfa)-AMC
NameBDBM257503
Synonyms:US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-(4-(5- methylpyrimidin-2-yl)phenyl)-3- phenylcyclopropanecarboxamide
TypeSmall organic molecule
Emp. Form.C21H18FN3O2
Mol. Mass.363.3849
SMILESCc1cnc(nc1)-c1ccc(cc1)[C@@H]1[C@@H](c2ccccc2)[C@@]1(F)C(=O)NO |r|
Structure
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